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A 3-year-old is brought to the emergency department having
just ingested a large overdose of chlorpropamide, an oral antidiabetic drug.
Chlorpropamide is a weak acid with a pKa of 5.0. It is capable of entering most
tissues. On physical examination, the heart rate is 110/min, blood pressure
90/50 mm Hg, and respiratory rate 30/min. Which of the following statements
about this case of chlorpropamide overdose is most correct?

(A) Urinary excretion would be accelerated by administration
of NH4Cl, an acidifying agent

(B) Urinary excretion would be accelerated by giving NaHCO3,
an

A 3-year-old is brought to the emergency department having
just ingested a large overdose of chlorpropamide, an oral antidiabetic drug.
Chlorpropamide is a weak acid with a pKa of 5.0. It is capable of entering most
tissues. On physical examination, the heart rate is 110/min, blood pressure
90/50 mm Hg, and respiratory rate 30/min. Which of the following statements
about this case of chlorpropamide overdose is most correct?

(A) Urinary excretion would be accelerated by administration
of NH4Cl, an acidifying agent

(B) Urinary excretion would be accelerated by giving NaHCO3,
an alkalinizing agent

(C) Less of the drug would be ionized at blood pH than at
stomach pH

(D) Absorption of the drug would be slower from the stomach
than from the small intestine